You can leave the filament attached to the spool while using your pen, however, you want to leave enough filament available so that you do not accidentally pull it and drop your spool. We've also found that as the filament draws into the Quil, the motor inside the pen isn't powerful enough to keep the spool turning. Be mindful to always have enough filament rolled out of your spool to prevent extrusion slow downs.
If you don't want to bother paying attention to the spool at all, you can also cut a good amount of the filament you plan on using for your print which might make it a bit more comfortable to use your pen. Once you run out you can get some more from the spool and continue your print without any issues.
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